Many Attend HIV Protease Inhibitor Symposium

William J. Martone, MD, Senior Executive Director of the National Foundation for Infectious Diseases (NFID), recently served as Co-Chair of a symposium which followed the 3rd Conference on Human Retroviruses and Opportunistic Infections. HIV Protease Inhibitors: When and How They Should Be Used was sponsored by The Thomas R. Beam, Jr., Memorial Institute for Continuing Medical Education in cooperation with NFID. The program was held in Washington, DC, on February 1. HIV Protease Inhibitors: When and How They Should Be Used was sponsored by the Thomas R. Beam, Jr., Memorial Institute for Continuing Medical Education in cooperation with NFID, and was made possible by an unrestricted educational grant from Merck and Co.

Topics presented at the symposium included an historical perspective and basic science of HIV protease inhibitors, their pharmacokinetics and pharmacodynamics, overview of resistance and cross-resistance, evaluation of plasma r-RNA as a surrogate marker in the treatment of HIV infection, and safety profile of inhibitors. The didactic program ended with a clinician's practice perspectives on the use of HIV protease inhibitors presented by Jay Dobkin, MD, Medical Director, AIDS Center, Columbia Presbyterian Medical Center, New York. A roundtable discussion followed the didactic program.

Dr. Martone, who co-chaired the session with John P. Phair, MD, Chief of the Division of Infectious Diseases, Northwestern University Medical School, believes that the topic was timely and appropriate for the audience, most of whom attended the Retrovirus Conference. "This was an important conference for those clinicians currently using or contemplating use of this exciting new class of anti-retroviral agents," he said.

Other faculty included Ann C. Collier, MD, Staff Investigator, Aaron Diamond AIDS Research Center and Professor of Medicine, New York University School of Medicine, Charles W. Flexner, MD, Assistant Professor of Medicine, Clinical Pharmacology and Infectious Diseases and Molecular Science, Johns Hopkins University School of Medicine, Martin H. Markowitz, MD, Staff Investigator, Aaron Diamond AIDS Research Center and Assistant Professor of Medicine, New York University School of Medicine; and John Mellors, MD, Associate Professor of Medicine, University of Pittsburgh Medical Center.

NFID and Pfizer Support Improvement of NNIS Data Quality

The National Foundation for Infectious Diseases (NFID) and Pfizer, Inc. are helping to improve the quality of data for the Center for Disease Control and Prevention's (CDC) National Nosocomial Infection Surveillance system (NNIS). Each year since 1992 NFID and Pfizer have sponsored annual training courses designed to improve the understanding of NNIS member surveillance personnel in NNIS methodology and data collection and reporting systems.

More than 220 hospitals in the United States participate in the NNIS system by routinely sending to CDC nosocomial infection data. Data are collected and reported using NNIS surveillance protocols and software entitled NNIS IDEAS. NNIS provides aggregated risk-adjusted infection rates that can be used by hospitals for comparison purposes as a measure of quality of care.

"NNIS data are also used by scientists and health care strategists to understand the epidemiology of nosocomial infections in the United States, including the growing problem of antimicrobial-resistant nosocomial pathogens," said T. Grace Emori, RN, MS, a senior member of CDC's NNIS staff. Hospitals not directly participating in NNIS can still benefit from NNIS data if they conduct surveillance using NNIS protocols. NNIS periodically publishes infection rates, the most recent report appearing in the December 1995 issue of the American Journal of Infection Control.

The training course is an intensive 3-day experience that includes hands-on use of the IDEAS surveillance software. About 20 NNIS member surveillance personnel attend each course. Funding for their travel and lodging expenses to attend the course is provided by NFID and Pfizer.


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