First Annual Conference on Vaccine Research (1998)

Saturday, May 30, 1998

Welcome and Introductions
William J. Martone, MD
National Foundation for Infectious Diseases
Keynote Address
Promoting Vaccine Discovery: A Vision for the Future Robert F. Breiman, MD
Centers for Disease Control and Prevention
Symposium 1: Issues in Clinical and Field Trials: Design, Execution, and Analysis
Moderator:
Myron M. Levine, MD, DTPH
University of Maryland
Experimental Challenge Models to Test the Efficacy of Enteric, Respiratory, and Other Vaccines in Volunteers -- Rationale, Advantages, and Limitations
Carol O. Tacket, MD
University of Maryland School of Medicine
Evaluating the Performance of New Vaccines: Efficacy vs. Effectiveness
John D. Clemens, MD
National Institutes of Health
Challenges in HIV Vaccine Development: Institutional Roles and Response
Mary Lou Clements-Mann, MD
The Johns Hopkins University
Symposium 2: Correlates of Immunity: The Role of Surrogate Markers
Moderator:
David S. Krause, MD
SmithKline Beecham Pharmaceuticals
Introduction to Surrogate Markers
David S. Krause, MD
SmithKline Beecham Pharmaceuticals
Lessons from the Past
George R. Siber, MD
Wyeth-Lederle Vaccines and Pediatrics
A Regulatory Perspective
Karen Midthun, MD
U. S. Food and Drug Administration
Panel Discussion
Submitted Presentations 1
Symposium 3: Maternal Immunization as a Strategy to Protect Offspring
Moderator:
Pamela M. McInnes, DDS
National Institutes of Health
Maternal Immunization: Current Successes and Future Strategies
Pamela M. McInnes, DDS
National Institutes of Health
Immunological Aspects of Maternal Immunization
Richard A. Insel, MD
University of Rochester School of Medicine
Maternal Immunization: The Two for One Group B Streptococcal Prevention Model
Carol Baker, MD
Baylor College of Medicine
Maternal Immunization: Prevention of Respiratory Disease
W. Paul Glezen, MD
Baylor College of Medicine
Panel Discussion
Sunday, May 31, 1998
Symposium 4: Immunomodulators and Adjuvants
Moderator:
Frederick R. Vogel, PhD
National Institutes for Health
Overview of Immunomodulators and Adjuvants
Frederick R. Vogel, PhD
National Institutes for Health
Novel Adjuvants for Hepatitis B Protein and DNA Vaccines
Michael J. Caulfield, PhD
Merck Research Laboratories
Rational Design and Development of Adjuvant-Active Nonionic Block Copolymers
Mark J. Newman, PhD
Vaxcel, Inc.
Submitted Presentations 2
Symposium 5: Combination Vaccine Strategies
Moderator:
Peter R. Paradiso, PhD
Wyeth-Lederle Vaccines and Pediatrics
Introduction to Combination Vaccines
Peter R. Paradiso, PhD
Wyeth-Lederle Vaccines and Pediatrics
Clinical Experience with Combination Vaccines
Scott A. Halperin, MD
Dalhousie University
IWK Grace Health Center
Immunological Considerations: Interference in Combination Vaccines
Steve Black, MD
Kaiser Permanente Vaccine Study Center
Panel Discussion
Submitted Presentations 3
Symposium 6: Mechanisms of Immune Evasion
Moderator:
Peter L. Nara, DVM, PhD
Biological Mimetics, Inc.
International Society for Vaccines
Introduction
Peter L. Nara, DVM, PhD
Biological Mimetics, Inc.
International Society for Vaccines
Molecular Mimicry in Murine Leishmaniasis
Nicolas Glaichenhaus, PhD
Université de Nice-Sophia Antipolis
Centre National de la Recherche Scientifique
Immunodominance and Immune Response to Tumor Antigens
Hans Schreiber, MD, PhD
University of Chicago
Effects of the First or Dominant Immune Response
Don A. Rowley, MD
University of Chicago
Immunodominance in the Protective Immune Repertoire to Influenza Infection
D.B. Thomas, DPhil
National Institute for Medical Research
Symposium 7: Effect of Age on the Immune Response
Moderator:
Richard J. Duma, MD, PhD
Halifax Medical Center
Immunology and Aging: An Overview James E. Nagel, MD
National Institutes of Health
Questions and Answers
Effect of Nutrition on Immunoresponsiveness in the Aged
Ranjit Kumar Chandra, MD
Memorial University of Newfoundland
Effect of Aging on Immune Response to Vaccines: Lessons in Animal Models
Bradley S. Bender, MD
University of Florida
Gainesville Veterans Affairs Medical Center
Monday, June 1, 1998

Symposium 8: Vaccine Delivery Technologies: Beyond Needle and Syringe
Moderator:
Bruce G. Weniger, MD
Centers for Disease Control and Prevention
Overview: The Challenge to Immunization Practice by Increasing Numbers of Parenteral Vaccines
Bruce G. Weniger, MD
Centers for Disease Control and Prevention
Mucosal Administration of Vaccine Antigens
Pearay L. Ogra, MD
Children's Hospital, University of Texas Medical Branch
Intranasal and Oral Delivery of Vaccines: Clinical Experience with Cold-Adapted Intranasal Influenza
Robert Belshe, MD
St. Louis University School of Medicine
Needle-Free Parenteral Jet Injection: Past, Present, and Future
Glenn Austin
Program for Appropriate Technology in Health (PATH)
Panel Discussion
Submitted Presentations 4
Symposium 9: Veterinary and Comparative Models of Disease and Protection
Moderator:
M.H.V. Van Regenmortel, PhD
Institut de Biologie Moleculaire et Cellulaire
Analysis of Protective Immunity in FIV
Margaret J. Hosie, PhD
University of Glasgow Veterinary School
Antigenic Mimicry in Foot and Mouth Disease M.H.V. Van Regenmortel, PhD
Institut de Biologie Moleculaire et Cellulaire
Nutritional Effects on Vaccination
Mark E. Cook, PhD
University of Wisconsin at Madison
Panel Discussion
Submitted Presentations 5
Poster Session A: Novel Vaccines and Novel Delivery Methods
Poster Session B: Assessing Immunologic Response and Disease Protection I